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Nature. 1990 Nov 29;348(6300):419-26.

Crystal structure of an HIV-binding recombinant fragment of human CD4.

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  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.


CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4 determined at 2.3 A resolution reveals that the molecule has two intimately associated immunoglobulin-like domains. Residues implicated in HIV recognition by analysis of mutants and antibody binding are salient features in domain D1. Domain D2 is distinguished by a variation on the beta-strand topologies of antibody domains and by an intra-sheet disulphide bridge.

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