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Behav Brain Res. 2012 May 16;231(1):226-30. doi: 10.1016/j.bbr.2012.03.026. Epub 2012 Mar 26.

α-Synuclein knockout mice have cognitive impairments.

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  • 1Institute of Physiologically Active Compounds of RAS, Chernogolovka, Russia.


α-Synuclein is a member of the synuclein family of cytoplasmic, predominantly neuron-specific proteins. Considerable amount of α-synuclein is found in axons and presynaptic terminals of neurons located in brain areas responsible for emotions and memory. In the present study we have carried out behavioral evaluation of spatial and working long-term memory of α-synuclein knockout mice. Our data shows that α-synuclein knockout mice have reduced learning ability in tests requiring both working and spatial memory. For the first time we have demonstrated that α-synuclein is necessary for these types of learning.

Copyright © 2012 Elsevier B.V. All rights reserved.

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