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Small. 2012 Jun 25;8(12):1876-9. doi: 10.1002/smll.201102418. Epub 2012 Mar 29.

Microfluidic generation of acoustically active nanodroplets.

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  • 1Curriculum of Applied Science & Engineering - Material Science, University of North Carolina, 310 Taylor Hall, CB 7575, Chapel Hill, NC 27599, USA.


A microfluidic approach for the generation of perfluorocarbon nanodroplets as the primary emulsion with diameters as small as 300-400 nm is described. The system uses a pressure-controlled delivery of all reagents and increased viscosity in the continuous phase to drive the device into an advanced tip-streaming regime, which results in generation of droplets in the sub-micrometer range. Such nanodroplets may be appropriate for emerging biomedical applications.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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