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Leuk Res. 2012 Jul;36(7):931-5. doi: 10.1016/j.leukres.2012.03.002. Epub 2012 Mar 31.

Downregulation of IRS2 in myelodysplastic syndrome: a possible role in impaired hematopoietic cell differentiation.

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  • 1Hematology and Hemotherapy Center, University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil.

Abstract

Insulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known in myelodysplasia. We, herein, report a significantly lower IRS2 expression in MDS cells, compared to normal cells. IRS2 expression was reduced in high-risk, compared to low-risk disease, and positively correlated with neutrophil and platelet counts. IRS2 was upregulated during erythroid differentiation of CD34(+) cells from normal donors and low-risk MDS patients and also during erythroid, granulocytic and megakaryocytic differentiation in cell lines. These results suggest that defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in MDS.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22465474
[PubMed - indexed for MEDLINE]
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