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Clin Biochem. 2012 Jun;45(9):700-2. doi: 10.1016/j.clinbiochem.2012.02.028. Epub 2012 Mar 23.

Diurnal variation in lipoprotein-associated phospholipase A(2) (Lp-PLA(2)).

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  • 1Ball State University, Human Performance Laboratory, Clinical Exercise Physiology Program, Muncie, IN 47306, USA.



The aim of our study was to determine the diurnal variation of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an arterial-specific inflammatory enzyme implicated in the formation of vulnerable, rupture-prone plaque that can identify individuals at high risk for cardiovascular disease. Presently, the diurnal variation of Lp-PLA(2) is not known.


Ten men and 8 women (age range: 22-76 years) had a blood sample taken every 4 h over a 24-hour time period. Samples were analyzed for both Lp-PLA(2) mass and activity.


The mean coefficient of variation (CV) for Lp-PLA(2) mass was 5.9% (ranges from 2.5 to 9.4%) for the 18 subjects. Similarly, the mean CV for Lp-PLA(2) activity was 3.7% (ranges from 1.2 to 6.8%). There were no significant correlations between CV and any of the subject characteristics.


The diurnal variation of Lp-PLA(2) mass and activity is similar to that of well accepted lipoprotein risk factors. With the relatively low diurnal variability, there does not appear to be a need to make sure serial measurements of Lp-PLA(2) mass and activity are taken at the same time of the day.

Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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