Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2012 May;28(5):187-94. doi: 10.1016/j.pt.2012.02.008. Epub 2012 Mar 28.

Helminthic therapy: improving mucosal barrier function.

Author information

  • 1Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, NY 10010, USA.

Abstract

The epidemiology of autoimmune diseases and helminth infections led to suggestions that helminths could improve inflammatory conditions, which was then tested using animal models. This has translated to clinical investigations aimed at the safe and controlled reintroduction of helminthic exposure to patients suffering from autoimmune diseases (so-called 'helminthic therapy') in an effort to mitigate the inflammatory response. In this review, we summarize the results of recent clinical trials of helminthic therapy, with particular attention to mechanisms of action. Whereas previous reviews have emphasized immune regulatory mechanisms activated by helminths, we propose that enhancement of mucosal barrier function may have an equally important role in improving conditions of inflammatory bowel diseases.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22464690
[PubMed - indexed for MEDLINE]
PMCID:
PMC4015520
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk