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Mol Cell. 2012 Mar 30;45(6):706-7. doi: 10.1016/j.molcel.2012.03.012.

PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed.

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  • 1Centre de recherche du CHUQ-Pavillon CHUL, Cancer Axis, Québec, Canada.


Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.

Copyright © 2012 Elsevier Inc. All rights reserved.

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