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Centre de recherche du CHUQ-Pavillon CHUL, Cancer Axis, Québec, Canada.
Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.
Copyright © 2012 Elsevier Inc. All rights reserved.
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