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Prion. 2012 Jan-Mar;6(1):89-93. doi: 10.4161/pri.6.1.18429.

Comparative analysis of Japanese and foreign L-type BSE prions.

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  • 1Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan.


L-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE. To characterize the Japanese L-type BSE prion, we conducted a comparative study of the Japanese and foreign L-type BSE isolates. The L-type BSE isolates of Japan, Germany, France and Canada were intracerebrally inoculated into bovinized prion protein-overexpressing transgenic mice (TgBoPrP). All the examined L-type BSE isolates were transmitted to TgBoPrP mice, and no clear differences were observed in their biological and biochemical properties. Here, we present evidence that the Japanese and Canadian L-type BSE prions are identical to those from the European cases.

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