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Biochem Biophys Res Commun. 1990 Nov 15;172(3):1049-54.

Cloning and sequencing of human LH/hCG receptor cDNA.

Author information

  • 1Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.

Erratum in

  • Biochem Biophys Res Commun 1994 Jun 15;201(2):1057.

Abstract

We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87% identical overall with the previously cloned rat and porcine LH/hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively).

PMID:
2244890
[PubMed - indexed for MEDLINE]
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