Biochem Biophys Res Commun. 1990 Nov 15;172(3):1049-54.

Cloning and sequencing of human LH/hCG receptor cDNA.

Minegishi T, Nakamura K, Takakura Y, Miyamoto K, Hasegawa Y, Ibuki Y, Igarashi M, Minegish T [corrected to Minegishi T].

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Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.

Erratum in

Biochem Biophys Res Commun 1994 Jun 15;201(2):1057.

Abstract

We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87% identical overall with the previously cloned rat and porcine LH/hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively).

PMID:: 2244890; [PubMed - indexed for MEDLINE]

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GENBANK/M63108

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Glycoprotein hormone receptors - IUPHAR Database of Receptors and Ion Channels

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Cited by 10 PubMed Central articles

Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers. [J Anim Sci Biotechnol. 2012]
Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers.
Yu Y, Pang Y, Zhao H, Xu X, Wu Z, An L, Tian J. J Anim Sci Biotechnol. 2012 Nov 9; 3(1):35. Epub 2012 Nov 9.
Review Participation of signaling pathways in the derepression of luteinizing hormone receptor transcription. [Mol Cell Endocrinol. 2010]
Review Participation of signaling pathways in the derepression of luteinizing hormone receptor transcription.
Dufau ML, Liao M, Zhang Y. Mol Cell Endocrinol. 2010 Jan 27; 314(2):221-7. Epub 2009 May 21.
Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease. [Reprod Biol Endocrinol. 2003]
Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease.
Bukovsky A, Indrapichate K, Fujiwara H, Cekanova M, Ayala ME, Dominguez R, Caudle MR, Wimalsena J, Elder RF, Copas P, et al. Reprod Biol Endocrinol. 2003 Jun 3; 1:46. Epub 2003 Jun 3.

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Cloning and sequencing of human LH/hCG receptor cDNA.
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Biochem Biophys Res Commun. 1990 Nov 15 ;172(3):1049-54.

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