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BMC Geriatr. 2012 Mar 26;12:12. doi: 10.1186/1471-2318-12-12.

Study protocol for prevention of falls: a randomized controlled trial of effects of vitamin D and exercise on falls prevention.

Author information

  • 1The UKK Institute for Health Promotion Research, PO Box 30, FI-33501 Tampere, Finland. kirsti.uusi-rasi@uta.fi

Abstract

BACKGROUND:

Falls are the leading cause of unintentional injury and injury-related death among older people. In addition to physical activity, vitamin D also may affect balance and neuromuscular function. Low serum 25-hydroksivitamin D level increases the risk of bone loss, falls and fractures. Thus, an appropriate exercise program and sufficient vitamin D intake may significantly improve not only functional balance, but also balance confidence. Balance represents a complex motor skill determined by reaction time, muscle strength, and speed and coordination of movement.

METHODS/DESIGN:

A 2-year randomized double-blind placebo-controlled vitamin D and open exercise trial of 409 home-dwelling women 70 to 80 years of age comprising four study arms: 1) exercise + vitamin D (800 IU/d), 2) exercise + placebo, 3) no exercise + vitamin D (800 IU/d), 4) no exercise + placebo. In addition to monthly fall diaries, general health status, life style, bone health, physical functioning, and vitamin D metabolism will be assessed. The primary outcomes are the rate of falls and fall-related injuries. Secondary outcomes include changes in neuromuscular functioning (e.g. body balance, muscle strength), ADL- and mobility functions, bone density and structure, cardiovascular risk factors, quality of life and fear of falling.

DISCUSSION:

The successful completion of this trial will provide evidence on the effectiveness of exercise and vitamin D for falls reduction.

TRIAL REGISTRATION:

ClinicalTrial.gov -register (NCT00986466).

PMID:
22448872
[PubMed - indexed for MEDLINE]
PMCID:
PMC3342151
Free PMC Article
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