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BMC Gastroenterol. 2012 Mar 26;12:25. doi: 10.1186/1471-230X-12-25.

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH.

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  • 1Yokohama City University School of Medicine, Yokohama, Japan.

Abstract

BACKGROUND:

The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.

METHODS:

Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.

RESULTS:

The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).

CONCLUSIONS:

In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.

PMID:
22448810
[PubMed - indexed for MEDLINE]
PMCID:
PMC3342890
Free PMC Article

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