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PLoS One. 2012;7(3):e34010. doi: 10.1371/journal.pone.0034010. Epub 2012 Mar 20.

Expression of PRB, FKBP52 and HB-EGF relating with ultrasonic evaluation of endometrial receptivity.

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  • 1National Research Institute for Family Planning, Beijing, China.



To explore the molecular basis of the different ultrasonic patterns of the human endometrium, and the molecular marker basis of local injury.


The mRNA and protein expression of FKBP52, progesterone receptor A (PRA), progesterone receptor B (PRB), and HB-EGF were detected in different patterns of the endometrium by real-time RTPCR and immunohistochemistry. There were differences in the mRNA and protein expression of FKBP52, PRB, and HB-EGF in the triple line (Pattern A) and homogeneous (Pattern C) endometrium in the window of implantation. No difference was detected in PRA expression. After local injury, the mRNA expression of HB-EGF significantly increased. In contrast, there was no difference in the mRNA expression of FKBP52, PRB, or PRA. The protein expression of FKBP52, PRB, and HB-EGF increased after local injury. There was no difference in the PRA expression after local injury.


PRB, FKBP52, and HB-EGF may be the molecular basis for the classification of the ultrasonic patterns. HB-EGF may be the molecular basis of local injury. Ultrasonic evaluation on the day of ovulation can be effective in predicting the outcome of implantation.

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