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Nat Genet. 2012 Mar 25;44(5):522-5. doi: 10.1038/ng.2227.

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.

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  • 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Abstract

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.

PMID:
22446961
[PubMed - indexed for MEDLINE]
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