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Gene Expr Patterns. 2012 May-Jun;12(5-6):172-9. doi: 10.1016/j.gep.2012.03.001. Epub 2012 Mar 16.

Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.

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  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Abstract

The development of the organ of Corti and the highly specialized cells required for hearing involves a multitude of genes, many of which remain unknown. Here we describe the expression pattern of three genes not previously studied in the inner ear in mice at a range of ages both embryonic and early postnatal. Kcna10, a tetrameric Shaker-like potassium channel, is expressed strongly in the hair cells themselves. Odf2, as its centriolar isoform Cenexin, marks the dendrites extending to and contacting hair cells, and Pxn, a focal adhesion scaffold protein, is most strongly expressed in pillar cells during the ages studied. The roles of these genes are yet to be elucidated, but their specific expression patterns imply potential functional significance in the inner ear.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22446089
[PubMed - indexed for MEDLINE]
PMCID:
PMC3368262
Free PMC Article

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