Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2012 Mar 23;335(6075):1458-62. doi: 10.1126/science.1216210.

Photoacoustic tomography: in vivo imaging from organelles to organs.

Author information

  • 1Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. lhwang@wustl.edu

Abstract

Photoacoustic tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs. This emerging technology overcomes the high degree of scattering of optical photons in biological tissue by making use of the photoacoustic effect. Light absorption by molecules creates a thermally induced pressure jump that launches ultrasonic waves, which are received by acoustic detectors to form images. Different implementations of PAT allow the spatial resolution to be scaled with the desired imaging depth in tissue while a high depth-to-resolution ratio is maintained. As a rule of thumb, the achievable spatial resolution is on the order of 1/200 of the desired imaging depth, which can reach up to 7 centimeters. PAT provides anatomical, functional, metabolic, molecular, and genetic contrasts of vasculature, hemodynamics, oxygen metabolism, biomarkers, and gene expression. We review the state of the art of PAT for both biological and clinical studies and discuss future prospects.

PMID:
22442475
[PubMed - indexed for MEDLINE]
PMCID:
PMC3322413
Free PMC Article

Images from this publication.See all images (3)Free text

Fig. 1
Fig. 2
Fig. 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk