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Sci Transl Med. 2012 Mar 21;4(126):126ps7. doi: 10.1126/scitranslmed.3003563.

Merging systems biology with pharmacodynamics.

Author information

  • 1Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA. ravi.iyengar@mssm.edu

Abstract

The emerging discipline of systems pharmacology aims to combine analysis and computational modeling of cellular regulatory networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized precision medicine. Here, we introduce the concept of enhanced pharmacodynamic (ePD) models, which synergistically combine the desirable features of systems biology and current PD models within the framework of ordinary or partial differential equations. ePD models that analyze regulatory networks involved in drug action can account for a drug's multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. This new knowledge can drive drug discovery and shape precision medicine.

PMID:
22440734
[PubMed - indexed for MEDLINE]
PMCID:
PMC3405973
Free PMC Article

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