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Cancer Cell. 2012 Mar 20;21(3):297-308. doi: 10.1016/j.ccr.2012.02.014.

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.

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  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Cancer metabolism has long been equated with aerobic glycolysis, seen by early biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures of cancer cells are not passive responses to damaged mitochondria but result from oncogene-directed metabolic reprogramming required to support anabolic growth. Recent evidence suggests that metabolites themselves can be oncogenic by altering cell signaling and blocking cellular differentiation. No longer can cancer-associated alterations in metabolism be viewed as an indirect response to cell proliferation and survival signals. We contend that altered metabolism has attained the status of a core hallmark of cancer.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22439925
[PubMed - indexed for MEDLINE]
PMCID:
PMC3311998
Free PMC Article
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