Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Carcinog. 2012;11:4. doi: 10.4103/1477-3163.93001. Epub 2012 Feb 17.

Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges.

Author information

  • 1Department of Molecular Biology and Immunology, and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX, USA.

Abstract

Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic changes in tumor cells resulting in the activation of growth factor receptors, signaling proteins, kinases, transcription factors and coregulators, and multiple proteases required for the progression of the disease. Recent advances provide novel insights into the molecular functions of these oncogenic activators, implicating potential therapeutic targeting opportunities for the treatment of prostate cancer.

KEYWORDS:

PI3K-Akt; Prostate cancer; growth factor receptors; oncogene; proteases; signaling pathways

PMID:
22438770
[PubMed]
PMCID:
PMC3307249
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
    Loading ...
    Write to the Help Desk