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J Cardiothorac Surg. 2012 Mar 21;7:25. doi: 10.1186/1749-8090-7-25.

Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study.

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  • 1Department of Cardiovascular and Thoracic Surgery, University Hospital of Larissa, Thessaly, Greece. gtagarakis@gmail.com



To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium.


We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.).


Both ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. DISCUSSION-CONCLUSIONS: Ondasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future.

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