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J Cardiothorac Surg. 2012 Mar 21;7:25. doi: 10.1186/1749-8090-7-25.

Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study.

Author information

  • 1Department of Cardiovascular and Thoracic Surgery, University Hospital of Larissa, Thessaly, Greece. gtagarakis@gmail.com

Abstract

BACKGROUND:

To investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium.

METHODS:

We included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.).

RESULTS:

Both ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. DISCUSSION-CONCLUSIONS: Ondasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future.

PMID:
22436170
[PubMed - indexed for MEDLINE]
PMCID:
PMC3378452
Free PMC Article

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