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Front Neuroinform. 2012 Mar 14;6:3. doi: 10.3389/fninf.2012.00003. eCollection 2012.

Models of the aging brain structure and individual decline.

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  • 1Structural Brain Mapping Group, Department of Psychiatry, Jena University Hospital Jena, Germany.


The aging brain's structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual variations of structural decline, using a repeated measures design. We concentrate our overview on preprocessed neuroanatomical images of the human brain to facilitate practical applications to diverse voxel- and surface-based structural markers. Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters.


aging, brain morphometry, inter-individual differences, longitudinal analysis, modeling, multivariate analysis

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