Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Front Neuroinform. 2012 Mar 14;6:3. doi: 10.3389/fninf.2012.00003. eCollection 2012.

Models of the aging brain structure and individual decline.

Author information

  • 1Structural Brain Mapping Group, Department of Psychiatry, Jena University Hospital Jena, Germany.

Abstract

The aging brain's structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual variations of structural decline, using a repeated measures design. We concentrate our overview on preprocessed neuroanatomical images of the human brain to facilitate practical applications to diverse voxel- and surface-based structural markers. Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters.

KEYWORDS:

aging, brain morphometry, inter-individual differences, longitudinal analysis, modeling, multivariate analysis

PMID:
22435060
[PubMed]
PMCID:
PMC3303090
Free PMC Article

Images from this publication.See all images (8)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk