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Muscle Nerve. 2012 Apr;45(4):586-96. doi: 10.1002/mus.22343.

Oxidative capacity and fatigability in run-trained malignant hyperthermia-susceptible mice.

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  • 1Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, P.O. Box 3975, Atlanta, Georgia 30302-3975, USA.



The purpose of this study was to test the hypothesis that malignant hyperthermia model mice (RyR1Y522S/wt) are more vulnerable to exercise-induced muscle injury and fatigability and adapt less to run training.


After 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) and citrate synthase (CS).


Although RyR1Y522S/wt mice ran without undergoing MH episodes, they ran 42% less distance than wild-type (WT) mice. Muscles from WT mice exhibited increased fatigue resistance and COX content after training. Muscles from RyR1Y522S/wt mice demonstrated no significant change in fatigability or COX and CS after training. However, muscles from RyR1Y522S/wt mice displayed less intrinsic fatigability and greater COX/CS content and muscle damage than WT mice.


RyR1Y522S/wt mice can run without having rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance.

Copyright © 2012 Wiley Periodicals, Inc.

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