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J Am Vet Med Assoc. 1990 Oct 15;197(8):1045-8.

Prednisolone and danazol for treatment of immune-mediated anemia, thrombocytopenia, and ineffective erythroid regeneration in a dog.

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  • 1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.


Immune-mediated anemia and thrombocytopenia were diagnosed in an 8-year-old spayed Miniature Schnauzer. The initial CBC indicated poor erythroid regeneration and concurrent leukopenia. The results of a Coombs test and ANA titer were strongly positive. Examination of a bone marrow specimen revealed erythrophagocytosis and a maturation arrest in the RBC series. Treatment with transfusion plus prednisolone and an attenuated androgen (danazol) resulted in stabilization of the PCV and the development of reticulocytosis.

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