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Gynecol Endocrinol. 2012 May;28(5):375-7. doi: 10.3109/09513590.2011.633649. Epub 2012 Mar 20.

PCOS and peripheral AMH levels in relation to FSH receptor gene single nucleotide polymorphisms.

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  • 1Department of Reproductive Medicine, St.Mary's Hospital, Manchester, UK.

Abstract

OBJECTIVES:

To determine if an association exists between the follicle-stimulating hormone receptor (FSHR) gene p.Asn680Ser polymorphism and polycystic ovary syndrome (PCOS) or with high anti-mullerian hormone (AMH) levels without PCOS.

PATIENTS:

Fifty-eight women with PCOS, 24 women with high AMH (>44.5 pmol/L) without PCOS and 80 healthy ethnically matched female controls.

MAIN OUTCOME MEASURES:

Prevalence of the FSHR p.Asn680Ser polymorphism, baseline serum AMH levels and response to ovulation induction with clomiphene citrate.

RESULTS:

The frequency of FSHR p.Asn680Ser genotypes were not significantly different between PCOS patients, patients with high AMH without PCOS and controls (p = 0.88). Of the women with PCOS, 34/58 were on clomiphene citrate treatment and 12/34 were resistant. There was no association between sensitivity or resistance to clomiphene and p.Asn680Ser genotypes (p = 0.38).

CONCLUSIONS:

There is no evidence that FSHR p.Asn680Ser genotypes are associated with PCOS, high AMH levels or response to clomiphene citrate.

PMID:
22429116
[PubMed - indexed for MEDLINE]
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