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Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260.

Structure of the activating IL-1 receptor signaling complex.

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  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA.

Abstract

Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1β bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.

PMID:
22426547
[PubMed - indexed for MEDLINE]
PMCID:
PMC4006550
Free PMC Article
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