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Infect Agent Cancer. 2012 Mar 15;7(1):6. doi: 10.1186/1750-9378-7-6.

HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma.

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  • 1Department of Medicine, Division of Infectious Diseases, University of California, San Diego, 150 West Washington St, San Diego, CA 92103, USA. shmorris@ucsd.edu.

Abstract

In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04).

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