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J Am Chem Soc. 2012 Apr 4;134(13):5798-800. doi: 10.1021/ja211601k. Epub 2012 Mar 23.

Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors.

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  • 1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

Abstract

PARACEST redox sensors containing the NAD(+)/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu(3+) complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu(3+) complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.

PMID:
22420507
[PubMed - indexed for MEDLINE]
PMCID:
PMC3321733
Free PMC Article
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