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[The relationship between glycogen synthase kinase-3 beta (GSK3B) -50T/C -1727A/T polymorphisms and alcoholism].

[Article in Japanese]

Author information

  • 1Laboratory of Neurophysiology, the Graduate School of Environmental, Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.

Abstract

As a help of the mechanism elucidation of alcoholism, we studied the relationship between glycogen synthase kinase 3-beta (GSK3B) -50T/C and -1727A/T polymorphisms, which are reported to relate to bipolar disorder. We genotyped the two polymorphisms in GSK3B gene using a polymerase chain reaction (PCR) in 71 health controls and 47 alcoholics. In this study, there was no significant difference in the frequency of GSK3B -50T/C and -1727A/T polymorphisms between alcoholics and controls. We suggested that there was no significant association of GSK3B -50T/C and -1727A/T polymorphisms with alcoholism.

PMID:
22413565
[PubMed - indexed for MEDLINE]
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