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Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1073-87. doi: 10.1098/rstb.2011.0207.

Assembly and mechanisms of bacterial type IV secretion machines.

Author information

  • 1Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50/I, Graz 8010, Austria. ellen.zechner@uni-graz.at

Abstract

Type IV secretion occurs across a wide range of prokaryotic cell envelopes: Gram-negative, Gram-positive, cell wall-less bacteria and some archaea. This diversity is reflected in the heterogeneity of components that constitute the secretion machines. Macromolecules are secreted in an ATP-dependent process using an envelope-spanning multi-protein channel. Similar to the type III systems, this apparatus extends beyond the cell surface as a pilus structure important for direct contact and penetration of the recipient cell surface. Type IV systems are remarkably versatile in that they mobilize a broad range of substrates, including single proteins, protein complexes, DNA and nucleoprotein complexes, across the cell envelope. These machines have broad clinical significance not only for delivering bacterial toxins or effector proteins directly into targeted host cells, but also for direct involvement in phenomena such as biofilm formation and the rapid horizontal spread of antibiotic resistance genes among the microbial community.

PMID:
22411979
[PubMed - indexed for MEDLINE]
PMCID:
PMC3297438
Free PMC Article

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