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Diabetologia. 2012 Jun;55(6):1685-8. doi: 10.1007/s00125-012-2518-0. Epub 2012 Mar 13.

Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals.

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  • 1Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, 430030 Wuhan, People's Republic of China.

Abstract

AIMS/HYPOTHESIS:

Variants of the high-mobility group A1 (HMGA1) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes.

METHODS:

Polymorphisms in HMGA1 were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls.

RESULTS:

We confirmed the association of the HMGA1 variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56, p = 0.0002 under a dominant model, and 95% CI 1.16, 1.55, p = 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%.

CONCLUSIONS/INTERPRETATION:

HMGA1 is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.

PMID:
22411136
[PubMed - indexed for MEDLINE]
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