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J Acquir Immune Defic Syndr. 2012 Apr 15;59(5):494-7. doi: 10.1097/QAI.0b013e31824c8397.

Ectopic fat is linked to prior cardiovascular events in men with HIV.

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  • 1Department of Medicine and Medical Specialties, University of Modena and Reggio Emilia, Modena, Italy.

Erratum in

  • J Acquir Immune Defic Syndr. 2012 Aug 1;60(4):e120. Gabriella, Orlando [corrected to Orlando, Gabriella]; Giovanni, Guaraldi [corrected to Guaraldi, Giovanni]; Stefano, Zona [corrected to Zona, Stefano]; Federica, Carli [corrected to Carli, Federica]; Pietro, Bagni [corrected to Bagni, Pietro]; Marianna, Menozzi [corrected to Menozzi, Marianna]; Stefania, Cocchi [corrected to Cocchi, Stefania]; Riccardo, Scaglioni [corrected to Scaglioni, Riccardo]; Guido, Ligabue [corrected to Ligabue, Guido]; Paolo, Raggi [corrected to Raggi, Paolo].


Epicardial Adipose Tissue (EAT) has been associated with adverse cardiovascular events in the general population. We studied the association of general adiposity measures (body mass index, waist circumference) and ectopic adipose tissue [visceral adipose tissue (VAT); liver fat (LF); EAT) with prevalent cardiovascular disease (CVD) (prior myocardial infarction, coronary revascularization, stroke, peripheral vascular disease] in 583 HIV-infected men. VAT, EAT, and LF (liver/spleen attenuation ratio < 1.1) were measured by computed tomography. Patients' mean age was 48.5 ± 8.1 years, prior CVD was present in 33 (5.7%) patients. Factors independently associated with CVD on multivariable analyses were age [incidence-rate ratio (IRR) = 1.07, 95% confidence interval (CI): 1.02 to 1.12], smoking (IRR = 2.70, 95% CI: 1.22 to 6.01), Center for Disease Control group C (IRR = 3.09, 95% CI: 1.41 to 6.76), EAT (IRR = 1.13, 95% CI: 1.04 to 1.24, per 10 cm), LF (IRR = 1.17, 95% CI: 1.04 to 1.32), and VAT (IRR = 1.05, 95% CI: 1.00 to 1.10, per 10 cm). Ectopic fat but not general adiposity measures were associated with prevalent CVD in men with HIV.

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