Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks

J Med Chem. 2012 Jun 14;55(11):4896-933. doi: 10.1021/jm300065h. Epub 2012 Mar 27.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Apoproteins / metabolism
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Drug Discovery
  • Drug Interactions*
  • Heme / metabolism
  • Humans
  • Models, Biological
  • Pharmacokinetics*
  • Structure-Activity Relationship
  • Time Factors

Substances

  • Apoproteins
  • Cytochrome P-450 Enzyme Inhibitors
  • Heme
  • Cytochrome P-450 Enzyme System