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Ocul Immunol Inflamm. 2012 Apr;20(2):104-12. doi: 10.3109/09273948.2011.647228.

Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial.

Collaborators (464)

Jaffe GJ, Branchaud B, Day S, Lee A, Skalak C, Wood M, Baer C, Bryant J, Chavala S, Cusick M, Dayani P, Ehlers J, Kesen M, Melamud A, Qureshi JA, Scott AW, See RF, Shuler RK, Yeh S, Fernandes A, Gibbs D, Leef D, Martin DF, Srivastava S, Dunn JP, Arnold E, Barnabie PM, Boring J, Brown DM, Gan T, Livingston AG, Nolan KD, Reed T, Belair ML, Bolton SG, Brodine JB, Brune LM, Galor A, Jacobowitz A, Kapoor M, Kedhar S, Kim S, Leder HA, Morton Y, Nolan K, Peters GB, Soto P, Stevenson R, Tarver-Carr M, Wang Y, Foster CS, Bruner L, Hinkle DM, Johnson J, Marvell D, Siddique SS, Acevedo S, Anzaar F, Cesca T, Contero A, Fitzpatrick K, Lebron KQ, Morgan C, Patel N, Pinto J, Sprague J, Yilmaz T, Sen HN, Bono M, Cunningham D, Hayes D, Koutsandreas D, Krishnadev N, Larson T, Meleth AD, Nussenblatt RB, Sherry PR, Short GL, Smith W, Temple A, Bamji A, Coleman H, Davuluri G, Faia L, Gottlieb C, Jirawuthiworavong GV, Lew JC, Mercer R, Obiyor D, Perry CH, Potapova N, Weichel E, Wroblewski KJ, Yeh S, Latkany PA, Badamo J, Gallardo J, Lorenzo-Latkany M, Masini R, Morell S, Nour A, Sanchez M, Boyd KM, Jarczynski J, McGrosky M, Steinberg K, Stawell RJ, Breayley L, D'Sylva C, Glatz E, Hodgson L, Koukouras I, Lim L, Ling C, McIntosh R, Morrison JE, Newton A, Smallwood R, Zamir E, Hunt N, Jones L, Williams S, Merrill PT, Hulvey P, Kernbauer E, Voskuil-Marre DL, Gaynes B, Giannoulis C, Khan HS, Levine SJ, Toennessen S, Wang RC, Aguado H, Arceneaux S, Fish GE, Hesse N, Jaramillo D, Mackens M, Mutz K, Sanchez B, Arnwine J, Callanan D, Cummings K, Gray K, Howden S, Lightman S, Taylor S, Tronnberg R, Edwards K, Joshi L, Stubbs T, Towler H, Holland GN, Almanzor RD, Castellanos J, Hubschman JP, Johiro AK, Kalyani PS, Levinson RD, Ransome SS, Gonzales CR, Gupta A, Kapamajian MA, Kappel PJ, Freeman WR, Kozak I, Nguyen V, Powell D, Clark T, Cochran DE, Hedaya J, Kemper T, LeMoine JM, Loughran ME, Magana L, Mojana F, Morrison V, Oster SF, Wong IG, Acharya N, Brown D, Clay D, Khouri CM, Lee S, Lew M, Margolis TP, Stewart J, Goldstein DA, Castro-Malek AL, Crooke CE, Huntley M, Niec M, Pyatetsky D, Ramirez M, Tessler HH, Davis JL, Albini TA, Elizondo A, Pinto DA, Castaño D, Chin M, Ho M, Kovach JL, Lin RC, Mandelcorn E, Nguyen JK, Pacini A, Pineda S, Rebimbas J, Stepien KE, Teran C, Elner SG, Brown R, Fournier L, Gothrup JR, Hackel R, Hesselgrave M, Prusak R, Saxe SJ, Bergeron M, Blosser R, Chrisman-McClure C, Sizemore D, Kempen JH, Berger J, Drossner S, DuPont JC, Maguire AM, Petner J, Weeney L, Hopkins T, McCall D, McRay M, Will D, Xu W, Pavan PR, Leto J, Mayor L, McDonald K, Pautler SE, Saxon W, Soto J, Goldstein B, Klukoff A, Lombright L, Ortiz M, Scymanky S, Szalay DD, Fawzi A, Davis T, Douglass J, Linton J, Padilla M, Ramos S, Rao NA, Aguirre A, Chong L, Cisneros L, Corona E, Eliott D, Garcia J, Khurana R, Lim J, Mead R, Tsai JH, Vitale A, Bernstein PS, Carlstrom B, Gilman J, Hanseen S, Morris P, Ramirez D, Wegner K, Sheppard JD, Anthony B, Casper A, Felix-Kent L, Fernandez J, Scoper SV, Cole RD, Crawford N, Franklin L, Hamelin K, Martin J, Marx R, Schultz G, Webb J, Yeager P, Kim RY, Benz MS, Brown DM, Chen E, Fish RH, Friday SH, Major J Jr, Shawver L, Wong TP, De La Garza R, Mutz K, Rao PK, Weeks R, Apte RS, Blinder KJ, Hartz A, Light P, Shah GK, VanGelder R, Jabs DA, Altaweel MM, Holbrook JT, Kempen JH, Kurinij N, Jabs DA, Almanzor RD, Altaweel MM, Brown D, Dunn JP, Gilman J, Holbrook JT, Holland GN, Kempen JH, Kim RY, Kurinij N, Prusakowski N, Thorne JE, Bolton SG, Brune LM, Clark T, Hubbard L, Martin DF, Nussenblatt RB, Wittes J, Barlow WE, Hochberg M, Lyon AT, Palestine AG, Simon LS, Altaweel MM, Holbrook JT, Jabs DA, Kurinij N, Rosenbaum JT, Smith H, Kempen JH, Dunn JP, Jaffe GJ, Martin DF, Thorne JE, Acharya NR, Jabs DA, Kempen JH, Latkany PA, Nussenblatt RB, Vitale AT, VanGelder R, Almanzor RD, Alexander J, Boring JA, Gibbs D, Lee S, Thorne JE, Ng WP, Friedman DS, Adler A, Alexander J, Burke A, Holbrook JT, Katz J, Kempen JH, Prusakowski N, Reed S, Thorne JE, Ansari H, Cohen N, Modak S, Ng WP, Sugar EA, Drye L, Frick K, Holbrook JT, Katz J, Louis T, Van Natta ML, Modak S, Shade D, Jabs DA, Hilal Y, Nieves MA, Pascual K, Slutsky-Sanon JS, Glomp C, Stevens M, Kempen JH, Holbrook JT, Adler AL, Alexander J, Boring JA, Burke AE, Collins K, Dodge JD, Drye LT, Ewing CS, Frick KD, Friedman DS, Jackson R, Katz J, Lears AT, Livingston H, Louis TA, Meinert CL, Meinert JL, Morrison V, Nowakowski DJ, Prusakowski N, Shade DM, Smith RE, Steuernagle K, Sugar EA, Thorne JE, Tonascia JA, Van Natta ML, Zheng R, Chen P, Cohen N, Modak S, Ng WP, Shen W, Shiflett C, Tieman A, Altaweel MM, Benz WK, Chambers G, Christianson DJ, Domalpally A, Freund J, Gama V, Gangaputra S, Glander KE, Goulding A, Joyce JM, Kruse CN, Myers DJ, Reed S, Reimers JL, Remm A, Susman RA, Thayer D, Treichel E, Warren KJ, Watson SM, White JK, Wilhelmson T, Fleischli MA, Hafford D, Harris SE, Hubbard LD, Johnson KA, Nagle L, Padden-Lechten GE, Pohlman A, Sivesind P, Webster MK, Zhang G, Kurinij N.

Author information

  • 1National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. senh@nei.nih.gov

Abstract

PURPOSE:

To assess the prevalence of hypotony in patients with severe forms of uveitis.

METHODS:

The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified.

RESULTS:

Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR] = 5.0; p < .01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR = 3.1; p = .03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR = 0.1; p = .02), in Caucasian patients (OR = 0.1; p < .01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR = 22.9; p < .01).

CONCLUSIONS:

Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.

PMID:
22409563
[PubMed - indexed for MEDLINE]
PMCID:
PMC3610172
Free PMC Article
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