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J Magn Reson. 2012 Apr;217:41-7. doi: 10.1016/j.jmr.2012.02.008. Epub 2012 Feb 24.

A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate.

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  • 1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.


A rapid echo planar imaging sequence for dynamic imaging of [1-(13)C] lactate and [1-(13)C] pyruvate simultaneously was developed. Frequency-based separation of these metabolites was achieved by spatial shifting in the phase-encoded direction with the appropriate choice of echo spacing. Suppression of the pyruvate-hydrate and alanine resonances is achieved through an optimized spectral-spatial RF waveform. Signal sampling efficiency as a function of pyruvate and lactate excitation angle was simulated using two site exchange models. Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed.

Published by Elsevier Inc.

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