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HPB (Oxford). 2012 Apr;14(4):228-35. doi: 10.1111/j.1477-2574.2011.00432.x. Epub 2012 Jan 19.

Multi-institutional analysis of pancreatic adenocarcinoma demonstrating the effect of diabetes status on survival after resection.

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  • 1Surgery, University of Louisville, Louisville, KY 40202, USA.

Abstract

BACKGROUND:

The effect of diabetes on survival after resection pancreatic ductal carcinoma (PDAC) is unclear. The present study was undertaken to determine whether pre-operative diabetes has any predictive value for survival.

METHODS:

A retrospective review from seven centres was performed. Metabolic factors, tumour characteristics and outcomes of patients undergoing resection for PDAC were collected. Univariate and multivariable analyses were performed to determine factors associated with disease-free (DFS) and overall survival (OS).

RESULTS:

Of the 509 patients in the present study, 31.2% had diabetes. Scoring systems were devised to predict OS and DFS based on a training set (n= 245) and were subsequently tested on an independent set (n= 264). Pre-operative diabetes (P < 0.001), tumour size >2 cm (P= 0.001), metastatic nodal ratio >0.1 (P < 0.001) and R1 margin (P < 0.001) all correlated with DFS and OS on univariate analysis. Scoring systems were devised based on multivariable analysis of the above factors. Diabetes and the metastatic nodal ratio were the most important factors in each system, earning two points for OS and four points for DFS. These scoring systems significantly correlated with both DFS (P < 0.001) and OS (P < 0.001).

CONCLUSION:

Pre-operative diabetes status provides useful information that can help to stratify patients in terms of predicted post-operative OS and DFS.

© 2012 International Hepato-Pancreato-Biliary Association.

PMID:
22404260
[PubMed - indexed for MEDLINE]
PMCID:
PMC3371208
Free PMC Article

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