Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Paediatr. 2012 Jul;101(7):772-8. doi: 10.1111/j.1651-2227.2012.02656.x. Epub 2012 Mar 24.

Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study.

Author information

  • 1Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden. elin.kimland@mpa.se

Abstract

AIM:

To perform a nationwide investigation of paediatric drug use at Swedish hospitals, including an analysis of off-label drug use.

METHODS:

All paediatric hospitals in Sweden were invited to register all prescriptions to children, aged between 0 and 18, during two separate 2-day-periods in 2008. Data were reported and analysed with respect to licence status and proportion of and reasons for off-label drug use.

RESULTS:

Data on 11,294 prescriptions to 2947 paediatric patients were received. Drugs associated with pain relief, infection, prematurity, nutrition and surgery or anaesthesia were most commonly used. Paracetamol was the most frequently used drug on-label and also among the most commonly used off-label drugs. Nearly half (49%) of all administered prescriptions concerned unlicensed drugs, off-label drugs or extemporaneously prepared drugs. The corresponding rate among neonates was 69%. Lack of paediatric information in the Summary of Product Characteristics was the main reason for off-label classification.

CONCLUSIONS:

Paediatric off-label drug use is common at Swedish hospitals, and nearly half of all prescriptions were not documented for use in children. The findings emphasize a need for paediatric clinical studies as well as compilation of existing clinical experience and scattered evidence, particularly for drug treatment in infants and neonates.

© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

PMID:
22404126
[PubMed - indexed for MEDLINE]
PMCID:
PMC3437470
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk