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Methods Mol Biol. 2012;856:275-91. doi: 10.1007/978-1-61779-585-5_11.

Association mapping and disease: evolutionary perspectives.

Author information

  • 1deCODE Genetics, Reykjavik, Iceland.

Abstract

In this chapter, we give a short introduction to the genetics of complex disease with special emphasis on evolutionary models for disease genes and the effect of different models on the genetic architecture, and finally give a survey of the state-of-the-art of genome-wide association studies.

PMID:
22399463
[PubMed - indexed for MEDLINE]
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