Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Public Health. 2012 Apr;102(4):e3-10. doi: 10.2105/AJPH.2011.300596. Epub 2012 Feb 16.

Genetic, physiological, and lifestyle predictors of mortality in the general population.

Author information

  • 1Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.

Erratum in

  • Am J Public Health. 2013 Aug;103(8):e7.

Abstract

OBJECTIVES:

We investigated the quality of 162 variables, focusing on the contribution of genetic markers, used solely or in combination with other characteristics, when predicting mortality.

METHODS:

In 5974 participants from the Rotterdam Study, followed for a median of 15.1 years, 7 groups of factors including age and gender, genetics, socioeconomics, lifestyle, physiological characteristics, prevalent diseases, and indicators of general health were related to all-cause mortality. Genetic variables were identified from 8 genome-wide association scans (n = 19,033) and literature review.

RESULTS:

We observed 3174 deaths during follow-up. The fully adjusted model (C-statistic for 15-year follow-up [C15y] = 0.80; 95% confidence interval [CI] = 0.79, 0.81) predicted mortality well [corrected]. Most of the additional information apart from age and sex stemmed from physiological markers, prevalent diseases, and general health. Socioeconomic factors and lifestyle contributed meaningfully to mortality risk prediction with longer prediction horizon. Although specific genetic factors were independently associated with mortality, jointly they contributed little to mortality prediction (C(15y) = 0.56; 95% CI = 0.55, 0.57).

CONCLUSIONS:

Mortality can be predicted reasonably well over a long period. Genetic factors independently predict mortality, but only modestly more than other risk indicators.

PMID:
22397355
[PubMed - indexed for MEDLINE]
PMCID:
PMC3489349
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk