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Diabet Foot Ankle. 2012;3. doi: 10.3402/dfa.v3i0.12236. Epub 2012 Jan 10.

The pathogenesis of Charcot neuroarthropathy: current concepts.

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  • 1Podiatric Medicine and Surgery Residency Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.


The pathogenesis of Charcot neuroarthropathy (CN) has been poorly understood by clinicians and scientists alike. Current researchers have made progress toward understanding the cause of CN and possible treatment options. The authors review the current literature on the pathogenesis of this debilitating disorder and attempt to explain the roles of inflammation, bone metabolism, and advanced glycation end products.


Charcot neuroarthropathy; RANKL; diabetic neuropathy; inflammation; osteoclast

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