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Korean Circ J. 2012 Feb;42(2):100-6. doi: 10.4070/kcj.2012.42.2.100. Epub 2012 Feb 27.

Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus.

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  • 1Departemnt of Cardiology, The Catholic University of Korea College of Medicine, Seoul, Korea.

Abstract

BACKGROUND AND OBJECTIVES:

Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated the relationship among plasma TSP-1 concentration, DM, and coronary artery disease (CAD).

SUBJECTS AND METHODS:

The study involved 374 consecutive subjects with suspected CAD, who had undergone coronary angiography to evaluate effort angina. Patients were divided into four groups as follows: DM(-) and CAD(-), DM(-) and CAD(+), DM(+) and CAD(-), and DM (+) and CAD(+).

RESULTS:

We found that plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) (n=103) than those in other patients (n=271) (p<0.01). A multivariate analysis showed that male gender {odds ratio (OR), 2.728; 95% confidence interval (CI), 1.035-7.187}, high density lipoprotein-cholesterol (OR, 0.925; 95% CI, 0.874-0.980), glycated hemoglobin (OR, 1.373; 95% CI, 1.037-1.817), and plasma TSP-1 (OR, 1.004; 95% CI, 1.000-1.008) levels were independently associated with the presence of CAD in patients with DM.

CONCLUSION:

Plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) than those in other patients, and plasma TSP-1 levels were independently associated with the presence of CAD in patients with DM. These findings show a possible link between human plasma TSP-1 concentration and CAD in patients with DM.

KEYWORDS:

Coronary artery disease; Diabetes mellitus; Thrombospondin-1

PMID:
22396697
[PubMed]
PMCID:
PMC3291719
Free PMC Article

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