Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Magn Reson Imaging. 2012 Aug;36(2):476-82. doi: 10.1002/jmri.23612. Epub 2012 Mar 7.

A novel MRI-compatible brain ventricle phantom for validation of segmentation and volumetry methods.

Author information

  • 1Medical Biophysics, Medical Sciences Building, The University of Western Ontario, London, ON, Canada.

Abstract

PURPOSE:

To create a standardized, MRI-compatible, life-sized phantom of the brain ventricles to evaluate ventricle segmentation methods using T(1) -weighted MRI. An objective phantom is needed to test the many different segmentation programs currently used to measure ventricle volumes in patients with Alzheimer's disease.

MATERIALS AND METHODS:

A ventricle model was constructed from polycarbonate using a digital mesh of the ventricles created from the 3 Tesla (T) MRI of a subject with Alzheimer's disease. The ventricle was placed in a brain mold and surrounded with material composed of 2% agar in water, 0.01% NaCl and 0.0375 mM gadopentetate dimeglumine to match the signal intensity properties of brain tissue in 3T T(1) -weighted MRI. The 3T T(1) -weighted images of the phantom were acquired and ventricle segmentation software was used to measure ventricle volume.

RESULTS:

The images acquired of the phantom successfully replicated in vivo signal intensity differences between the ventricle and surrounding tissue in T(1) -weighted images and were robust to segmentation. The ventricle volume was quantified to 99% accuracy at 1-mm voxel size.

CONCLUSION:

The phantom represents a simple, realistic and objective method to test the accuracy of lateral ventricle segmentation methods and we project it can be extended to other anatomical structures.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
22396226
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk