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EMBO J. 2012 Apr 18;31(8):1879-92. doi: 10.1038/emboj.2012.43. Epub 2012 Mar 6.

Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates.

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  • 1Division of Developmental Neuroscience, United Core Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Abstract

Asymmetric cell division plays an indispensable role during corticogenesis for producing new neurons while maintaining a self-renewing pool of apical progenitors. The cellular and molecular determinants favouring asymmetric division are not completely understood. Here, we identify a novel mechanism for generating cellular asymmetry through the active transportation and local translation of Cyclin D2 mRNA in the basal process. This process is regulated by a unique cis-regulatory sequence found in the 3' untranslated region (3'UTR) of the mRNA. Unequal inheritance of Cyclin D2 protein to the basally positioned daughter cell with the basal process confers renewal of the apical progenitor after asymmetric division. Conversely, depletion of Cyclin D2 in the apically positioned daughter cell results in terminal neuronal differentiation. We demonstrate that Cyclin D2 is also expressed in the developing human cortex within similar domains, thus indicating that its role as a fate determinant is ancient and conserved.

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PMID:
22395070
[PubMed - indexed for MEDLINE]
PMCID:
PMC3343330
Free PMC Article

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