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Sheng Wu Gong Cheng Xue Bao. 2011 Nov;27(11):1541-8.

[Progress in improvement of lentiviral vectors' transcriptional read-through].

[Article in Chinese]

Author information

  • 1Shanghai Children's Hospital, Shanghai 200040, China.

Abstract

Four out of 10 patients of X-linked severe combined immunodeficiency (X-SCID) were finally developed leukemia after receiving the treatment of gene therapy delivered by gamma-retroviral vectors. This is due to the vector integrated to the proximity of lmo2 etc proto-oncogene promoters, leading to the activation of onco-gene expression, which raises the concern of the bio-safety of gene therapy vectors. Lentiviral vectors, especially self-inactivating lentiviral vectors, are considered to be much safer than gamma-retroviral vectors. However self-inactivating lentiviral vectors also have encountered with some unsafe factors and one of them is the problem of transcriptional "read-through" . During the past years, achievements have been made to reduce lentiviral vector transcriptional read-through, which are reviewed herein.

PMID:
22393708
[PubMed - indexed for MEDLINE]
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