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    Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006395. doi: 10.1101/cshperspect.a006395.

    Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.

    Aisen PS, Cummings J, Schneider LS.

    Source

    University of California, San Diego, California 92093, USA. paisen@ucsd.edu

    Abstract

    In this work we consider marketed drugs for Alzheimer disease (AD) including acetylcholinesterase inhibitors (AChE-Is) and antiglutamatergic treatment involving the N-methyl-d-aspartate (NMDA) receptor. We discuss medications and substances available for use as cognitive enhancers that are not approved for AD or cognitive impairment, and other neurotransmitter-related therapies in development or currently being researched. We also review putative therapies that aim to slow disease progression by mechanisms not directly related to amyloid or tau.

    PMID:
    22393531
    [PubMed - in process]
    PMCID:
    PMC3282492
    Free PMC Article

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      • Deciphering Alzheimer disease. [Cold Spring Harb Perspect Med....]
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        Selkoe D, Mandelkow E, Holtzman D. Cold Spring Harb Perspect Med. 2012 Jan; 2(1):a011460.

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