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J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S136-41. doi: 10.1016/j.jaci.2011.12.987.

Mediators of asthma outcomes.

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  • 1Johns Hopkins University, Baltimore, MD, USA.



Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators.


National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators.


We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature.


The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants.


Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.

Published by Mosby, Inc.

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