Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Exp Reprod Med. 2011 Mar;38(1):42-6. doi: 10.5653/cerm.2011.38.1.42. Epub 2011 Mar 31.

Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome.

Author information

  • 1Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea.

Abstract

OBJECTIVE:

This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS).

METHODS:

We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value<0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values.

RESULTS:

In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p=0.013 and p=0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p=0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p=0.000).

CONCLUSION:

In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.

KEYWORDS:

Biopsy; Endometrial Hyperplasia; Endometrium; Human; Polycystic Ovary Syndrome

PMID:
22384417
[PubMed]
PMCID:
PMC3283042
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for The Korean Society for Reproductive Medicine Icon for PubMed Central
    Loading ...
    Write to the Help Desk