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PLoS One. 2012;7(2):e32096. doi: 10.1371/journal.pone.0032096. Epub 2012 Feb 23.

Identification of cancer cell-line origins using fluorescence image-based phenomic screening.

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  • 1Biomolecules Function Research Center, Korea Institute of Science and Technology, Seoul, South Korea.

Abstract

Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

PMID:
22384151
[PubMed - indexed for MEDLINE]
PMCID:
PMC3285665
Free PMC Article
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