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Appl Microbiol Biotechnol. 2012 Apr;94(1):39-46. doi: 10.1007/s00253-012-3958-7. Epub 2012 Mar 1.

Dengue virus-like particles: construction and application.

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  • 1Department of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering under Educational Committee in Chongqing, Third Military Medical University, 30# Gaotanyan St, Shapingba District, Chongqing 400038, People's Republic of China.

Abstract

Virus-like particles (VLPs) are shell-like viruses that lack virus-specific genetic materials. Many viral-structured proteins can assemble into VLPs, which mimic the overall structure of virus particles and can elicit strong immune responses in a host. Dengue viruses (DENVs), from the genus Flavivirus, are transmitted to humans through the bites of an infected Aedes mosquito. DENVs cause several diseases that prevailed mainly in tropical and subtropical areas. However, effective treatment measures and preventive strategies for dengue diseases are still lacking. The present minireview summarized the assembly and maturation of DENVs, the strategies and effective factors for dengue VLP construction, and the application of DENV VLPs.

PMID:
22382168
[PubMed - indexed for MEDLINE]
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