Send to:

Choose Destination
See comment in PubMed Commons below
Case Rep Gastroenterol. 2012 Jan;6(1):33-9. doi: 10.1159/000336198. Epub 2012 Jan 16.

Spindle and giant cell type undifferentiated carcinoma of the proximal bile duct.

Author information

  • 1Department of Surgery, Saga University Faculty of Medicine, Saga, Japan.


Undifferentiated spindle and giant cell carcinoma is an extremely rare malignant neoplasm arising in the extrahepatic bile duct. We herein present the case of a 67-year-old male who developed an undifferentiated spindle and giant cell carcinoma of the proximal bile duct. A nodular infiltrating tumor was located at the proximal bile duct, resulting in obstructive jaundice. Histologically, the tumor was composed of mainly spindle-shaped and giant cells and showed positive immunoreactivity for both cytokeratin and vimentin. Adjuvant chemotherapy was administered following extrahepatic bile duct resection, and he has been doing well for 16 months since the surgical treatment. The literature on this rare malignancy is also reviewed and discussed.


Adjuvant chemotherapy; Bile duct cancer; Bile duct resection

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Write to the Help Desk