Send to

Choose Destination
See comment in PubMed Commons below
J Virol. 2012 May;86(10):5937-41. doi: 10.1128/JVI.06839-11. Epub 2012 Feb 29.

Four amino acids of an insect densovirus capsid determine midgut tropism and virulence.

Author information

  • 1Invivo AgroSolutions, Valbonne, France.


Densoviruses are insect parvoviruses that are orally infectious for Lepidoptera. To assess the mechanisms underlying their specificity and their virulence, we investigated the role of eight candidate residues in the densovirus capsid. We showed that the substitutions of four amino acids were associated with decreased virulence due to a decreased ability to cross the host midgut epithelium, without an effect on viral replication in other tissues.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk