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Clin Vaccine Immunol. 2012 Apr;19(4):623-5. doi: 10.1128/CVI.05705-11. Epub 2012 Feb 29.

Tick-borne encephalitis virus-neutralizing antibodies in different immunoglobulin preparations.

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  • 1Global Pathogen Safety, Baxter BioScience, Vienna, Austria.


Patients with primary immunodeficiency (PIDs) depend on the presence of a variety of antibody specificities in intravenous immunoglobulin (IVIG). Using the tick-borne encephalitis virus (TBEV), geographic variability in IVIG antibody content was shown. Care should therefore be exercised when treating PIDs in a given geography, as only locally sourced plasma contains the antibody specificities against the circulating pathogens in the given locality.

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